NASDAQ · Biotechnology

Fulcrum Therapeutics, Inc. (FULC) Stock

$3.68 +0.00% NASDAQ: FULC Healthcare

Valuation

MetricValue
Price$3.68
Market Cap$280.77M
P/E Ratio-3.05
P/B Ratio0.91
P/S Ratio0.00
EPS (TTM)$-1.18
52-Week High$15.74
52-Week Low$2.83
Dividend Yield0.00%

Financials & Margins

MetricValue
ROE-28.54%
ROA-26.24%
ROCE-27.62%
Gross Margin0.00%
Operating Margin0.00%
Net Margin0.00%
Debt/Equity0.02
Current Ratio27.46

Annual Financials (USD)

Metric20212022202320242025
Revenue$19.0M$6.0M$3.0M$80.0M$0
Operating Profit$-81.0M$-113.0M$-111.0M$-22.0M$-85.0M
Net Profit$-81.0M$-110.0M$-97.0M$-10.0M$-75.0M
EPS$-2.22$-2.35$-1.59$-0.16$-1.18
Op Margin-423.0%-1774.8%-3945.2%-27.4%—

Balance Sheet (USD)

Metric20212022202320242025
Total Assets$235.0M$227.0M$258.0M$261.0M$366.0M
Total Liabilities$23.0M$28.0M$23.0M$18.0M$17.0M
Cash$35.0M$35.0M$26.0M$58.0M$198.0M
Borrowings$0$13.0M$11.0M$9.0M$6.0M

Latest News

Fulcrum Therapeutics (FULC) Stock Fair Value Moves Lower After Pociredir Exit Simply Wall St. · Jun 27, 2026 A Look At Fulcrum Therapeutics (FULC) Valuation After Scrapping Lead Sickle Cell Drug And Restructuring Simply Wall St. · Jun 5, 2026 Fulcrum Therapeutics (FULC) Loses 51% in 4 Weeks, Here's Why a Trend Reversal May be Around the Corner Zacks · Jun 5, 2026 FULC Stock Crashes as Cancer Risk Forces Its Only Drug Program's End Zacks · Jun 3, 2026 JPMorgan Downgrades Fulcrum Therapeutics to Underweight From Overweight MT Newswires · Jun 3, 2026

Cash Flow (USD)

Metric20212022202320242025
Operating Cash Flow$-78.0M$-97.0M$-91.0M$-2.0M$-60.0M
Investing Cash Flow$-131.0M$10.0M$-37.0M$32.0M$30.0M
Financing Cash Flow$4.0M$4.0M$1.0M$0$0
Net Cash Flow$-22.0M$0$-10.0M$33.0M$139.0M
Free Cash Flow$-80.0M$-99.0M$-91.0M$-2.0M$-60.0M

Valuation & Return Ratios

MetricValue
PEG Ratio-8.05
EV / EBITDA-3.08
FCF Yield-23.49%
Quick Ratio31.35
Interest Coverage—
Return 1Y-52.47%
Return 3Y0.53%
Return 5Y-61.65%

Ownership

Insiders Held3.83%
Institutions Held126.06%
Institutions Float Held131.08%
Institutional HolderSharesReport Date
Suvretta Capital Management, LLC6,561,1112026-03-31
RA Capital Management, L.P.6,053,9602026-03-31
Blackrock Inc.5,390,5932026-03-31
TCG Crossover Management, LLC5,250,0002026-03-31
Braidwell LP 3,134,9222026-03-31

Peer Comparison

TickerPriceChangeP/EMarket CapDiv Yield
ADCTADC Therapeutics SA $1.44 -10.00% -2.14 $183.84M 0.00%
BCYCBicycle Therapeutics plc $4.22 +0.24% -1.34 $292.84M 0.00%
CMPXCompass Therapeutics, Inc. $0.76 -5.05% -2.06 $137.05M 0.00%
LCTXLineage Cell Therapeutics, Inc. $1.00 +1.52% -6.61 $252.91M 0.00%
LXRXLexicon Pharmaceuticals, Inc. $1.42 -4.70% -12.10 $631.84M 0.00%

About Fulcrum Therapeutics, Inc.

Fulcrum Therapeutics, Inc. is led by CEO Alexander C. Sapir, employs 45 people, headquartered in US, publicly traded since 2019.

Fulcrum Therapeutics, Inc. (FULC) stock trades at $3.68 with a market capitalization of $280.77M. The stock is valued at a negative price-to-earnings (P/E) ratio of -3.05, reflecting a net loss over the last twelve months, price-to-book of 0.91, price-to-sales of 0.00. Over the past 52 weeks the stock has ranged between $2.83 and $15.74, and currently trades 76.6% below its 52-week high.

On profitability, Fulcrum Therapeutics, Inc. generates a return on equity (ROE) of -28.54% (negative, reflecting a net loss), return on capital employed of -27.62%.

Fulcrum Therapeutics, Inc. by the numbers, 2017–2025

Between 2017 and 2025 Fulcrum Therapeutics, Inc. reported revenue of $0 rising to $0. Compounded, revenue has grown —% a year over five years, —% over three, —% over the last twelve months. Net profit fell to $-75.0M.

On a trailing twelve-month basis to Jun '26, revenue is $0 and net profit $-85.0M.

Borrowings fell from $35.0M to $6.0M, cash from operations was $-60.0M in the latest year, positive in 0 of the last 9.

Return on equity has averaged -32.1% over five years, and was -21.5% in the most recent year.

The share price itself has compounded at —% a year over five years, —% over three, —% over the last year. Past price movement is history, not a forecast.

Figures are as reported and in the company's own reporting currency. They describe what has already happened and carry no implication about what follows.

Fulcrum Therapeutics, Inc. (FULC) — frequently asked questions

What is Fulcrum Therapeutics, Inc. (FULC) stock price today?

Fulcrum Therapeutics, Inc. (FULC) is currently trading at $3.68, up 0% today.

What is FULC P/E ratio?

Fulcrum Therapeutics, Inc.'s P/E ratio is -3.05. A negative P/E means the company reported a net loss over the last twelve months, so P/E is not a meaningful valuation measure for it right now.

What is FULC return on equity (ROE)?

Fulcrum Therapeutics, Inc.'s return on equity (ROE) is -28.54%. ROE measures net income relative to shareholders' equity. A negative ROE means the company reported a net loss over the period.

What is Fulcrum Therapeutics, Inc.'s market cap?

Fulcrum Therapeutics, Inc. has a market capitalization of $280.77M.

Does FULC pay a dividend?

Fulcrum Therapeutics, Inc. is not currently showing a dividend yield in our data, which means no recent cash dividend was recorded for it.

How much debt does FULC carry?

Fulcrum Therapeutics, Inc. has a debt-to-equity ratio of 0.02. That compares total borrowings with shareholders' equity: a figure under 1 means equity exceeds debt.

What is FULC's profit margin?

Fulcrum Therapeutics, Inc. reports a net profit margin of 0.00% — the share of revenue left after every cost, including tax and interest.

What sector is FULC in?

Fulcrum Therapeutics, Inc. is classified under Healthcare, in the Biotechnology industry. Ratios are most informative compared with other companies in the same industry rather than across the whole market.

Which exchange is FULC listed on?

Fulcrum Therapeutics, Inc. trades on NASDAQ under the ticker FULC.

What is FULC's 52-week range?

Over the last year Fulcrum Therapeutics, Inc. has traded between $2.83 and $15.74.

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Screens FULC currently matches

On the figures above, Fulcrum Therapeutics, Inc. passes the filters for 6 of our ready-made screens, among them Penny Stocks, Stocks Under $5, Stocks Under $10. Appearing on a screen means the numbers meet its filters today and nothing more; the list is rebuilt whenever the data changes.

Penny StocksStocks Under $5Stocks Under $10Debt Free Stocks Under $100Micro Cap StocksDebt Free Micro Cap Stocks

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