Lexicon Pharmaceuticals, Inc. (LXRX) Stock

About Lexicon Pharmaceuticals, Inc.

Lexicon Pharmaceuticals, Inc. is led by CEO Michael S. Exton, employs 103 people, headquartered in US, publicly traded since 2000.

Lexicon Pharmaceuticals, Inc. (LXRX) stock trades at $1.42 with a market capitalization of $631.84M. The stock is valued at a negative price-to-earnings (P/E) ratio of -12.10, reflecting a net loss over the last twelve months, price-to-book of 4.56, price-to-sales of 19.49. Over the past 52 weeks the stock has ranged between $1.10 and $2.68, and currently trades 47.0% below its 52-week high.

On profitability, Lexicon Pharmaceuticals, Inc. generates a return on equity (ROE) of -40.40% (negative, reflecting a net loss), return on capital employed of -23.16%, an operating margin of -98.00%, a net profit margin of -147.38%.

Lexicon Pharmaceuticals, Inc. by the numbers, 2016–2025

Between 2016 and 2025 Lexicon Pharmaceuticals, Inc. reported revenue of $83.0M rising to $50.0M, a change of -39.8% across 10 years. Compounded, revenue has grown 15.8% a year over five years, —% over three, 61.3% over the last twelve months. Net profit rose to $-50.0M.

Operating margin went from -164.6% in 2016 to -98.2% in 2025, a gain of 66.4 percentage points. The most recent net margin is -147.38%. On a trailing twelve-month basis to Jun '26, revenue is $41.0M and net profit $-62.0M.

Borrowings fell from $101.0M to $62.0M, cash from operations was $-68.0M in the latest year, positive in 1 of the last 10.

Return on equity has averaged -107.6% over five years, and was -46.3% in the most recent year.

The share price itself has compounded at —% a year over five years, —% over three, —% over the last year. Past price movement is history, not a forecast.

Figures are as reported and in the company's own reporting currency. They describe what has already happened and carry no implication about what follows.

Lexicon Pharmaceuticals, Inc. (LXRX) — frequently asked questions