NASDAQ · Biotechnology

Alnylam Pharmaceuticals, Inc. (ALNY) Stock

$231.83 -0.94% NASDAQ: ALNY Healthcare

Valuation

MetricValue
Price$231.83
Market Cap$31.02B
P/E Ratio36.02
P/B Ratio21.62
P/S Ratio6.12
EPS (TTM)$3.99
52-Week High$495.55
52-Week Low$197.81
Dividend Yield0.00%

Financials & Margins

MetricValue
ROE93.61%
ROA14.54%
ROCE24.71%
Gross Margin13.52%
Operating Margin13.52%
Net Margin16.82%
Debt/Equity0.94
Current Ratio2.76

Annual Financials (USD)

Metric20212022202320242025
Revenue$844.0M$1.0B$1.8B$2.2B$3.7B
Operating Profit$-709.0M$-785.0M$-282.0M$-177.0M$502.0M
Net Profit$-853.0M$-1.1B$-440.0M$-278.0M$314.0M
EPS$-7.20$-9.30$-3.52$-2.18$2.33
Op Margin-83.9%-75.7%-15.4%-7.9%13.5%

Balance Sheet (USD)

Metric20212022202320242025
Total Assets$3.6B$3.5B$3.8B$4.2B$5.0B
Total Liabilities$3.1B$3.7B$4.1B$4.2B$4.2B
Cash$820.0M$866.0M$813.0M$966.0M$1.7B
Borrowings$998.0M$1.3B$1.3B$1.3B$1.3B

Latest News

Is Alnylam Pharmaceuticals (ALNY) Cheap As Rival Trial Failure Shifts ATTR CM Expectations? Simply Wall St. · Jul 11, 2026 Ionis Pharmaceuticals Drops Another 9% as Bad News Piles Up 24/7 Wall St. · Jul 10, 2026 Is Rival ATTR-CM Trial Failure and New AI Deals Altering The Investment Case For Alnylam (ALNY)? Simply Wall St. · Jul 10, 2026 Alnylam (ALNY) Gets An Opening In ATTR CM As Rival Trial Fails Simply Wall St. · Jul 10, 2026 Beyond The Breakout Drug: Is BridgeBio Pharma Stock A Buy On Its Next Act? Trefis · Jul 10, 2026

Cash Flow (USD)

Metric20212022202320242025
Operating Cash Flow$-642.0M$-541.0M$104.0M$-8.0M$524.0M
Investing Cash Flow$-350.0M$97.0M$-399.0M$-151.0M$378.0M
Financing Cash Flow$501.0M$-88.0M$25.0M$-9.0M$-8.0M
Net Cash Flow$323.0M$46.0M$-54.0M$154.0M$690.0M
Free Cash Flow$-718.0M$-613.0M$42.0M$-43.0M$465.0M

Valuation & Return Ratios

MetricValue
PEG Ratio0.01
EV / EBITDA25.17
FCF Yield1.85%
Quick Ratio2.99
Interest Coverage3.08
Return 1Y-51.14%
Return 3Y41.61%
Return 5Y11.34%

Peer Comparison

TickerPriceChangeP/EMarket CapDiv Yield
ARWRArrowhead Pharmaceuticals, Inc. $55.90 -4.44% -28.66 $7.90B 0.00%
IONSIonis Pharmaceuticals, Inc. $42.94 -2.67% -12.57 $7.14B 0.00%
NTLAIntellia Therapeutics, Inc. $11.42 +0.71% -3.65 $1.60B 0.00%
SLNSilence Therapeutics plc $9.80 -0.36% -2.57 $462.66M 0.00%
WVEWave Life Sciences, Inc. $3.13 -1.88% -3.47 $616.76M 0.00%

About Alnylam Pharmaceuticals, Inc.

Alnylam Pharmaceuticals, Inc. is led by CEO Yvonne L. Greenstreet, employs 2,230 people, headquartered in Cambridge, US, publicly traded since 2004.

Alnylam Pharmaceuticals, Inc. (ALNY) stock trades at $231.83 with a market capitalization of $31.02B. The stock is valued at a price-to-earnings (P/E) ratio of 36.02, price-to-book of 21.62, price-to-sales of 6.12. Over the past 52 weeks the stock has ranged between $197.81 and $495.55, and currently trades 53.2% below its 52-week high.

On profitability, Alnylam Pharmaceuticals, Inc. generates a return on equity (ROE) of 93.61%, above the typical market range of roughly 12-15%, return on capital employed of 24.71%, an operating margin of 13.52%, a net profit margin of 16.82%.

In its most recent fiscal year, Alnylam Pharmaceuticals, Inc. reported annual revenue of $3.7B, net profit of $314.0M. Revenue grew at an average annual rate of 49.8% over the last 5 fiscal years.

The balance sheet shows a debt-to-equity ratio of 0.94, a current ratio of 2.76, total assets of $5.0B, $1.7B in cash and equivalents.

ALNY has a beta of 0.30 (historically less volatile than the overall market).

Related Healthcare Stocks

LLY Eli Lilly and Company $1257.03 +0.43% JNJ Johnson & Johnson $255.56 +0.90% ABBV AbbVie Inc. $285.42 +0.71% UNH UnitedHealth Group Incorporated Common Stock (DE) $401.43 -1.29% MRK Merck & Company, Inc. Common Stock (new) $145.97 +0.53% NVS Novartis AG $150.62 +0.16% AZN AstraZeneca PLC $165.41 -0.76% TMO Thermo Fisher Scientific Inc $690.00 -0.93% AMGN Amgen Inc. $432.49 -0.35% GILD Gilead Sciences, Inc. $156.19 -0.75% ABT Abbott Laboratories $104.88 +0.19% NVO Novo Nordisk A/S $38.83 -0.99%

Popular Stocks

Apple (AAPL)Microsoft (MSFT)NVIDIA (NVDA)Alphabet (GOOGL)Amazon (AMZN)Meta (META)Tesla (TSLA)Broadcom (AVGO)JPMorgan (JPM)Visa (V)

Related stock screens

High ROE Healthcare StocksLow P/E Healthcare StocksHigh Net Margin Healthcare StocksDividend Healthcare StocksLow Debt Healthcare StocksNasdaq High ROE StocksAll stock screens
Run Stock Screener Investing Guides

Data for information only, not investment advice. Figures may be delayed or inaccurate; verify against company filings. See our disclaimer.