NASDAQ · Biotechnology

Amylyx Pharmaceuticals, Inc. (AMLX) Stock

$27.20 -4.80% NASDAQ: AMLX Healthcare

Valuation

MetricValue
Price$27.20
Market Cap$3.41B
P/E Ratio-19.71
P/B Ratio12.92
P/S Ratio0.00
EPS (TTM)$-1.53
52-Week High$41.14
52-Week Low$10.83
Dividend Yield0.00%

Financials & Margins

MetricValue
ROE-52.92%
ROA-57.49%
ROCE-66.60%
Gross Margin0.00%
Operating Margin0.00%
Net Margin0.00%
Debt/Equity0.02
Current Ratio14.09

Annual Financials (USD)

Metric20212022202320242025
Revenue$0$22.0M$381.0M$87.0M$0
Operating Profit$-83.0M$-201.0M$39.0M$-315.0M$-153.0M
Net Profit$-88.0M$-198.0M$49.0M$-302.0M$-145.0M
EPS$-1.52$-2.98$0.70$-4.43$-1.53
Op Margin—-905.7%10.2%-360.2%—

Balance Sheet (USD)

Metric20212022202320242025
Total Assets$106.0M$391.0M$517.0M$194.0M$333.0M
Total Liabilities$257.0M$51.0M$84.0M$29.0M$27.0M
Cash$50.0M$63.0M$170.0M$77.0M$227.0M
Borrowings$0$6.0M$4.0M$2.0M$6.0M

Latest News

Post-Bariatric Hypoglycemia Market to Register Stunning Growth at a 16.4% CAGR Through 2036 Owing to the Emergence of Novel Drug Classes Such as GLP-1 Receptor Antagonists, SGLT1 Inhibitors, CRH Inhibitors, and SSTR5 Agonists | DelveInsight PR Newswire · Jul 7, 2026 Is Amylyx Pharmaceuticals, Inc. (AMLX) Stock Ready for a Breakout Ahead of Key LUCIDITY Trial Data? Insider Monkey · Jun 30, 2026 Amylyx Pharmaceuticals to Present Data from First-in-Human, Dose-Ranging Phase 1 LUMINA Trial of AMX0114 in ALS at ENCALS 2026 Business Wire · Jun 23, 2026 Amylyx Pharmaceuticals Eyes Q3 Phase 3 Avexitide Readout as PBH Launch Plans Take Shape MarketBeat · Jun 10, 2026 Amylyx Pharmaceuticals Announces Poster Presentations at ENDO 2026 Business Wire · Jun 8, 2026

Cash Flow (USD)

Metric20212022202320242025
Operating Cash Flow$-75.0M$-180.0M$12.0M$-168.0M$-123.0M
Investing Cash Flow$-47.0M$-242.0M$91.0M$75.0M$14.0M
Financing Cash Flow$-2.0M$-1.0M$-3.0M$-2.0M$-3.0M
Net Cash Flow$37.0M$13.0M$108.0M$-92.0M$149.0M
Free Cash Flow$-75.0M$-182.0M$11.0M$-168.0M$-123.0M

Valuation & Return Ratios

MetricValue
PEG Ratio-0.33
EV / EBITDA-20.34
FCF Yield-4.10%
Quick Ratio12.12
Interest Coverage—
Return 1Y268.79%
Return 3Y60.09%
Return 5Y—

Ownership

Insiders Held7.89%
Institutions Held105.37%
Institutions Float Held114.39%
Institutional HolderSharesReport Date
FMR, LLC16,630,5412026-03-31
Blackrock Inc.8,828,8362026-03-31
Perceptive Advisors Llc8,284,8822026-03-31
TCG Crossover Management, LLC6,243,8122026-03-31
Commodore Capital Lp5,650,0002026-03-31

About Amylyx Pharmaceuticals, Inc.

Amylyx Pharmaceuticals, Inc. is led by CEO Joshua Cohen, employs 123 people, headquartered in US, publicly traded since 2022.

Amylyx Pharmaceuticals, Inc. (AMLX) stock trades at $27.20 with a market capitalization of $3.41B. The stock is valued at a negative price-to-earnings (P/E) ratio of -19.71, reflecting a net loss over the last twelve months, price-to-book of 12.92, price-to-sales of 0.00. Over the past 52 weeks the stock has ranged between $10.83 and $41.14, and currently trades 33.9% below its 52-week high.

On profitability, Amylyx Pharmaceuticals, Inc. generates a return on equity (ROE) of -52.92% (negative, reflecting a net loss), return on capital employed of -66.60%.

Amylyx Pharmaceuticals, Inc. by the numbers, 2019–2025

Between 2019 and 2025 Amylyx Pharmaceuticals, Inc. reported revenue of $1.0M rising to $0, a change of -100.0% across 7 years. Compounded, revenue has grown —% a year over five years, —% over three, —% over the last twelve months. Net profit fell to $-145.0M.

On a trailing twelve-month basis to Jun '26, revenue is $0 and net profit $-151.0M.

Borrowings fell from $15.0M to $6.0M, cash from operations was $-123.0M in the latest year, positive in 1 of the last 7.

Return on equity has averaged -43.8% over five years, and was -47.5% in the most recent year.

The share price itself has compounded at —% a year over five years, —% over three, —% over the last year. Past price movement is history, not a forecast.

Figures are as reported and in the company's own reporting currency. They describe what has already happened and carry no implication about what follows.

Amylyx Pharmaceuticals, Inc. (AMLX) — frequently asked questions

What is Amylyx Pharmaceuticals, Inc. (AMLX) stock price today?

Amylyx Pharmaceuticals, Inc. (AMLX) is currently trading at $27.20, down 4.8% today.

What is AMLX P/E ratio?

Amylyx Pharmaceuticals, Inc.'s P/E ratio is -19.71. A negative P/E means the company reported a net loss over the last twelve months, so P/E is not a meaningful valuation measure for it right now.

What is AMLX return on equity (ROE)?

Amylyx Pharmaceuticals, Inc.'s return on equity (ROE) is -52.92%. ROE measures net income relative to shareholders' equity. A negative ROE means the company reported a net loss over the period.

What is Amylyx Pharmaceuticals, Inc.'s market cap?

Amylyx Pharmaceuticals, Inc. has a market capitalization of $3.41B.

Does AMLX pay a dividend?

Amylyx Pharmaceuticals, Inc. is not currently showing a dividend yield in our data, which means no recent cash dividend was recorded for it.

How much debt does AMLX carry?

Amylyx Pharmaceuticals, Inc. has a debt-to-equity ratio of 0.02. That compares total borrowings with shareholders' equity: a figure under 1 means equity exceeds debt.

What is AMLX's profit margin?

Amylyx Pharmaceuticals, Inc. reports a net profit margin of 0.00% — the share of revenue left after every cost, including tax and interest.

What sector is AMLX in?

Amylyx Pharmaceuticals, Inc. is classified under Healthcare, in the Biotechnology industry. Ratios are most informative compared with other companies in the same industry rather than across the whole market.

Which exchange is AMLX listed on?

Amylyx Pharmaceuticals, Inc. trades on NASDAQ under the ticker AMLX.

What is AMLX's 52-week range?

Over the last year Amylyx Pharmaceuticals, Inc. has traded between $10.83 and $41.14.

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Screens AMLX currently matches

On the figures above, Amylyx Pharmaceuticals, Inc. passes the filters for 8 of our ready-made screens, among them Low Debt Stocks, Debt Free Stocks Under $100, Debt Free Stocks. Appearing on a screen means the numbers meet its filters today and nothing more; the list is rebuilt whenever the data changes.

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