NASDAQ · Biotechnology

Annexon, Inc. (ANNX) Stock

$3.75 -1.57% NASDAQ: ANNX Healthcare

Valuation

MetricValue
Price$3.75
Market Cap$614.41M
P/E Ratio-3.61
P/B Ratio4.53
P/S Ratio0.00
EPS (TTM)$0.00
52-Week High$7.18
52-Week Low$2.54
Dividend Yield0.00%

Financials & Margins

MetricValue
ROE-106.15%
ROA-82.36%
ROCE-101.43%
Gross Margin0.00%
Operating Margin0.00%
Net Margin0.00%
Debt/Equity0.13
Current Ratio5.63

Annual Financials (USD)

Metric20212022202320242025
Revenue$0$0$0$0$0
Operating Profit$-131.0M$-146.0M$-144.0M$-154.0M$-216.0M
Net Profit$-130.0M$-142.0M$-134.0M$-138.0M$-207.0M
EPS$-3.34$-2.60$-1.77$-1.01$-1.34
Op Margin—————

Balance Sheet (USD)

Metric20212022202320242025
Total Assets$287.0M$285.0M$298.0M$350.0M$278.0M
Total Liabilities$55.0M$54.0M$47.0M$57.0M$66.0M
Cash$75.0M$140.0M$225.0M$49.0M$162.0M
Borrowings$35.0M$33.0M$31.0M$29.0M$26.0M

Latest News

Annexon to Present Phase 2 ARCHER Baseline Characteristics Associated with Confirmed Best Corrected Visual Acuity 15-Letter Loss in Patients with Geographic Atrophy at ASRS 2026 GlobeNewswire · Jul 14, 2026 Annexon Reports Inducement Grants to New Employees Under Nasdaq Listing Rule 5635(c)(4) GlobeNewswire · Jun 16, 2026 Annexon Eyes ‘Win Season’ With Q4 Vision Trial Data, GBS Filings Ahead MarketBeat · Jun 9, 2026 Exploring 3 High Growth Tech Stocks in the US Market Simply Wall St. · Jun 9, 2026 Annexon Maps 3 Big Pipeline Catalysts Ahead of Q4 Vision-Drug Readout MarketBeat · Jun 4, 2026

Cash Flow (USD)

Metric20212022202320242025
Operating Cash Flow$-106.0M$-116.0M$-121.0M$-118.0M$-186.0M
Investing Cash Flow$-90.0M$52.0M$71.0M$-219.0M$190.0M
Financing Cash Flow$0$-8.0M$0$-1.0M$-2.0M
Net Cash Flow$-194.0M$65.0M$85.0M$-176.0M$113.0M
Free Cash Flow$-108.0M$-123.0M$-121.0M$-118.0M$-186.0M

Valuation & Return Ratios

MetricValue
PEG Ratio-0.42
EV / EBITDA-2.56
FCF Yield-28.15%
Quick Ratio5.53
Interest Coverage—
Return 1Y113.71%
Return 3Y61.59%
Return 5Y-75.26%

Ownership

Insiders Held0.49%
Institutions Held102.39%
Institutions Float Held102.90%
Institutional HolderSharesReport Date
Redmile Group, LLC14,549,7682026-03-31
Blackrock Inc.10,938,5092026-03-31
FMR, LLC10,635,6482026-03-31
BVF Inc.8,698,1732026-03-31
State Street Corporation6,919,2552026-03-31

About Annexon, Inc.

Annexon, Inc. is led by CEO Douglas E. Love, employs 106 people, headquartered in US, publicly traded since 2020.

Annexon, Inc. (ANNX) stock trades at $3.75 with a market capitalization of $614.41M. The stock is valued at a negative price-to-earnings (P/E) ratio of -3.61, reflecting a net loss over the last twelve months, price-to-book of 4.53, price-to-sales of 0.00. Over the past 52 weeks the stock has ranged between $2.54 and $7.18, and currently trades 47.8% below its 52-week high.

On profitability, Annexon, Inc. generates a return on equity (ROE) of -106.15% (negative, reflecting a net loss), return on capital employed of -101.43%.

Annexon, Inc. by the numbers, 2017–2025

Between 2017 and 2025 Annexon, Inc. reported revenue of $0 rising to $0. Compounded, revenue has grown —% a year over five years, —% over three, —% over the last twelve months. Net profit fell to $-207.0M.

On a trailing twelve-month basis to Jun '26, revenue is $0 and net profit $-202.0M.

Borrowings fell from $49.0M to $26.0M, cash from operations was $-186.0M in the latest year, positive in 0 of the last 9.

Return on equity has averaged -63.1% over five years, and was -97.6% in the most recent year.

The share price itself has compounded at —% a year over five years, —% over three, —% over the last year. Past price movement is history, not a forecast.

Figures are as reported and in the company's own reporting currency. They describe what has already happened and carry no implication about what follows.

Annexon, Inc. (ANNX) — frequently asked questions

What is Annexon, Inc. (ANNX) stock price today?

Annexon, Inc. (ANNX) is currently trading at $3.75, down 1.57% today.

What is ANNX P/E ratio?

Annexon, Inc.'s P/E ratio is -3.61. A negative P/E means the company reported a net loss over the last twelve months, so P/E is not a meaningful valuation measure for it right now.

What is ANNX return on equity (ROE)?

Annexon, Inc.'s return on equity (ROE) is -106.15%. ROE measures net income relative to shareholders' equity. A negative ROE means the company reported a net loss over the period.

What is Annexon, Inc.'s market cap?

Annexon, Inc. has a market capitalization of $614.41M.

Does ANNX pay a dividend?

Annexon, Inc. is not currently showing a dividend yield in our data, which means no recent cash dividend was recorded for it.

How much debt does ANNX carry?

Annexon, Inc. has a debt-to-equity ratio of 0.13. That compares total borrowings with shareholders' equity: a figure under 1 means equity exceeds debt.

What is ANNX's profit margin?

Annexon, Inc. reports a net profit margin of 0.00% — the share of revenue left after every cost, including tax and interest.

What sector is ANNX in?

Annexon, Inc. is classified under Healthcare, in the Biotechnology industry. Ratios are most informative compared with other companies in the same industry rather than across the whole market.

Which exchange is ANNX listed on?

Annexon, Inc. trades on NASDAQ under the ticker ANNX.

What is ANNX's 52-week range?

Over the last year Annexon, Inc. has traded between $2.54 and $7.18.

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Screens ANNX currently matches

On the figures above, Annexon, Inc. passes the filters for 8 of our ready-made screens, among them Penny Stocks, Small Cap Stocks, Stocks Under $5. Appearing on a screen means the numbers meet its filters today and nothing more; the list is rebuilt whenever the data changes.

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Data for information only, not investment advice. Figures may be delayed or inaccurate; verify against company filings. See our disclaimer.